Year : 2014  |  Volume : 5  |  Issue : 2  |  Page : 93-99

Folic acid supplementation on homocysteine levels in children taking antiepileptic drugs: A randomized controlled trial

1 Department of Pharmacology, Government Medical College, Calicut, Kerala, India
2 Department of Community Medicine, Government Medical College, Calicut, Kerala, India
3 Department of Paediatrics, Government Medical College, Calicut, Kerala, India
4 Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
5 Department of Nuclear Medicine, Government Medical College, Calicut, Kerala, India

Correspondence Address:
Thayyil Jayakrishnan
Department of Community Medicine, Government Medical College, Calicut, Kerala, India

Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-500X.130048

Rights and Permissions

Objectives: To assess the level of homocysteine (tHcy) in children taking AEDs and to study whether daily oral supplementation of folic acid for 1 month will reduce the tHcy level. Materials and Methods: This was a double-blinded, randomized control trial conducted in Institute of Maternal and Child Health, Kozhikode, India. Totally 60 children were recruited and of them, 48 were enrolled. Of these children, 32 were assigned to the experimental group and 16 to the control group. Baseline data collection and tHcy estimation were done. One mg folic acid tablets were given to the experimental group and placebo tablets to the control group for 30 days. tHcy levels were re-estimated after 1 month follow-up. Statistical significance was tested by χ2 test, and paired and unpaired t-tests, as appropriate. Correlation was tested by Pearson correlation test and P value less than 0.05 was taken as the cut-off for statistical significance. Results: Baseline plasma tHcy concentrations in both groups were comparable [11.90 (6.3) and 13.02 (2.4) μmol/l, respectively]. During the follow-up period, no increase in seizure episodes or no serious adverse reactions were noticed in either group. The reduction of tHcy in the experimental group was 1.92 μmol/l (P = 0.04) and in the control group, there was an increase of 1.05 μmol/l (P = 0.16). Conclusions: In children on AED treatment, folic acid supplementation may reduce tHcy level and thus reduce CVD risk.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded581    
    Comments [Add]    
    Cited by others 2    

Recommend this journal