Phosphodiesterase-4 inhibition with rolipram attenuates hepatocellular injury in hyperinflammation in vivo and in vitro without influencing inflammation and HO-1 expression

Jakob Wollborn¹, Christian Wunder¹, Jana Stix², Winfried Neuhaus³, Rapahel R Bruno¹, Wolfgang Baar⁴, Sven Flemming⁵, Norbert Roewer¹, Nicolas Schlegel⁵, Martin A Schick^1
1 Department of Anaesthesia and Critical Care, University Hospital Würzburg, Germany
² Department of Pathology, Klinikum Nürnberg, Nürnberg, Germany
³ Department of Anaesthesia and Critical Care, University Hospital Würzburg, Germany; Department of Medicinal Chemistry, University of Vienna, Vienna, Austria
⁴ Department of Anaesthesia and Critical Care, University Hospital Würzburg; Department of Anesthesiology and Critical Care Medicine, University Medical Center, Freiburg, Germany
⁵ Department of General, Visceral, Vascular, and Paediatric Surgery (Department of Surgery I), University of Würzburg, Würzburg, Germany

Correspondence Address:
Martin A Schick
Department of Anaesthesia and Critical Care, University Hospital Würzburg
Germany

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0976-500X.149138