Year : 2015  |  Volume : 6  |  Issue : 2  |  Page : 98-99

Hypokalemia and rhabdomyolysis

1 Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Denmark
2 Department of Internal Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark

Correspondence Address:
Henrik Horwitz
Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-500X.155488

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The adverse drug event manager of the Capital Region of Denmark received a report of a 65-year-old male with type II diabetes and long-lasting treatment with indapamide. In addition, he had a history of a high consumption of licorice. For 2 weeks, the patient suffered from myalgia, which the general practitioner suspected to be polymyalgia rheumatica and referred him to the hospital. Initial blood samples revealed a reduced potassium concentration of 1.5 mmol/L (reference value: 6.6-4.6 mmol/L) and an elevated creatine kinase of 18,400 IU/L (reference value: 40-280 IU/L). We believe that the patient developed rhabdomyolysis due to severe hypokalemia, possibly induced by a pharmacodynamic interaction between licorice and indapamide.

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