Year : 2015  |  Volume : 6  |  Issue : 3  |  Page : 188-192

Naloxegol: First oral peripherally acting mu opioid receptor antagonists for opioid-induced constipation

Department of Pharmacology, Armed Forces Medical College, Pune, Maharashtra, India

Correspondence Address:
Tejus Anantharamu
Department of Pharmacology, Armed Forces Medical College, Pune, Maharashtra
Login to access the Email id

Source of Support: Nil, Conflict of Interest: None declared.

DOI: 10.4103/0976-500X.162015

Rights and Permissions

Opioid-induced constipation (OIC) is one of the most troublesome and the most common effects of opioid use leading to deterioration in quality of life of the patients and also has potentially deleterious repercussions on adherence and compliance to opioid therapy. With the current guidelines advocating liberal use of opioids by physicians even for non-cancer chronic pain, the situation is further complicated as these individuals are not undergoing palliative care and hence there cannot be any justification to subject these patients to the severe constipation brought on by opioid therapy which is no less debilitating than the chronic pain. The aim in these patients is to prevent the opioid-induced constipation but at the same time allow the analgesic activity of opioids. Many drugs have been used with limited success but the most specific among them were the peripherally acting mu opioid receptor antagonists (PAMORA). Methylnaltrexone and alvimopan were the early drugs in this group but were not approved for oral use in OIC. However naloxegol, the latest PAMORA has been very recently approved as the first oral drug for OIC. This article gives an overview of OIC, its current management and more specifically the development and approval of naloxegol, including pharmacokinetics, details of various clinical trials, adverse effects and its current status for the management of OIC.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded704    
    Comments [Add]    
    Cited by others 5    

Recommend this journal