Year : 2015  |  Volume : 6  |  Issue : 4  |  Page : 222-224

Sodium thiosulfate for the treatment of warfarin-induced calciphylaxis in a nondialysis patient

Department of Pharmacy Practice, The University of Mississippi School of Pharmacy, Jackson, Mississippi, USA

Correspondence Address:
Emily J Carrell
213 CR 162, Oxford, Mississippi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-500X.171882

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Calciphylaxis or uremic arteriolopathy is a complex process typically seen in patients with end-stage renal disease, but has also been reported in patients with normal renal function. However, therapies for calciphylaxis are based on reports of traditional patients (i.e., end-stage renal disease). A mainstay of therapy, sodium thiosulfate (STS), has been shown to be effective for the treatment of calciphylaxis. Without a standardized therapy reported for nondialysis patients there is a need for evidence-based therapy. Here, we report a case of a 63-year-old woman with an acute injury on chronic kidney disease (CrClBaseline = 48 mL/min, CrClAKI = 36 mL/min), not requiring dialysis, with warfarin-induced calciphylaxis. After 4 weeks of therapy with STS, sevelamer, alendronate, and enzymatic debridement the patient subjectively reported slight improvement of the necrotic ulcers but developed cellulitis on her nonaffected limb. Additionally, after 12 weeks of therapy she was readmitted for renal failure and subsequently required dialysis.

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