Year : 2016  |  Volume : 7  |  Issue : 2  |  Page : 80-86

Effect of losartan and atenolol on insulin sensitivity in nondiabetic hypertensive patients

1 Department of Pharmacology, SMBT Institute of Medical Sciences and Research Centre, Dhamangaon, Nashik, Maharashtra, India
2 Department of Pharmacology, Armed Forces Medical College, Pune, Maharashtra, India

Correspondence Address:
Sandesh Madhukar Bharati
Department of Pharmacology, SMBT Institute of Medical Sciences and Research Centre, Nandi Hills, Dhamangaon-Ghoti, Igatpuri, Nashik - 422 403, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-500X.184771

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Objective: To study the effects of losartan and atenolol on glucometabolic parameters in nondiabetic hypertensive patients. Materials and Methods: In a prospective, open-label, parallel group study, nondiabetic patients with mild to moderate hypertension were randomized to either losartan (titrated from 50 to 100 mg/day, n = 20) or atenolol (titrated from 25 mg to 100 mg/day, n = 20) for period of 24 weeks. At baseline, 12 and 24 weeks fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment for insulin resistance (HOMA-IR) apart from lipid parameters, mean systolic, and diastolic blood pressures levels were determined. Results: At the end of study, losartan significantly (P < 0.05) reduced FPG, FPI, and HOMA-IR compared to atenolol and baseline. While atenolol increased the HOMA-IR levels significantly compared to the baseline. Conclusions: Losartan improved the insulin sensitivity while atenolol worsened it. Losartan is better than atenolol for its effects on the glucose-insulin metabolism.

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