Year : 2017  |  Volume : 8  |  Issue : 3  |  Page : 122-127

Cardioprotective effect of coenzyme Q10on apoptotic myocardial cell death by regulation of bcl-2 gene expression

1 Department of Pharmacology, School of Pharmaceutical Sciences, IFTM University, Moradabad, Uthra Pradesh, India
2 Department of Health Information Technology, Jeddah Community College, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia
3 Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
4 Department of Internal Medicine and Geriatric Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia
5 Department of Pharmacy, M.J.P. Rohilkhand University, Bareilly, Uthra Pradesh, India

Correspondence Address:
Najam Ali Khan
Department of Pharmacology, School of Pharmaceutical Sciences, IFTM University, Moradabad - 244 001, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpp.JPP_47_17

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Objectives: To investigate the effect of coenzyme Q10 (CoQ10) on apoptotic myocardial cell death in rat model of heart ischemia and reperfusion I/R injury. Materials and Methods: Eighteen rats (200–250 g) were divided into three groups of 6 rats in each. Group I (sham-operated control group): this is the control group. The animals received the surgical procedure without IR injury or any drug treatment. Group II (I/R group): ischemia was accomplished by the occlusion of coronary artery for 30 min followed by reperfusion for 45 min and Group-III (Coenzyme Q10treated group): Treated with CoQ10at a dose of 1 mg/kg, postoperative for 7 days before induction of IR injury. Results: The study revealed that pretreatment with CoQ10has shown protective effect on apoptotic rat heart and agreed with earlier reports that CoQ10significantly protects from oxidative stress and cytopathological changes caused by cardiac ischemia followed by reperfusion and attenuated decrease of antioxidant enzymes. Nitric oxide production in the heart of ischemic rats was significantly increased by the pretreatment with CoQ10in comparison with IR group. Conclusions: CoQ10protects against cardiac apoptosis induced by IR injury by significantly decreasing the apoptotic DNA and regulating the expression of Bcl-2 gene.

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