Journal of Pharmacology and Pharmacotherapeutics

EDUCATIONAL FORUM
Year
: 2011  |  Volume : 2  |  Issue : 2  |  Page : 74--79

Toxicological screening


S Parasuraman 
 Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Correspondence Address:
S Parasuraman
Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry
India

Toxicity testing of new compounds is essential for drug development process. The preclinical toxicity testing on various biological systems reveals the species-, organ- and dose- specific toxic effects of an investigational product. The toxicity of substances can be observed by (a) studying the accidental exposures to a substance (b) in vitro studies using cells/ cell lines (c) in vivo exposure on experimental animals. This review mainly focuses on the various experimental animal models and methods used for toxicity testing of substances. The pre-clinical toxicity testing helps to calculate DQNo Observed Adverse Effect LevelDQ which is needed to initiate the clinical evaluation of investigational products.


How to cite this article:
Parasuraman S. Toxicological screening.J Pharmacol Pharmacother 2011;2:74-79


How to cite this URL:
Parasuraman S. Toxicological screening. J Pharmacol Pharmacother [serial online] 2011 [cited 2020 Oct 25 ];2:74-79
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2011;volume=2;issue=2;spage=74;epage=79;aulast=Parasuraman;type=0