Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2011  |  Volume : 2  |  Issue : 3  |  Page : 158--164

Antibiotic sensitivity profile of bacterial pathogens in postoperative wound infections at a tertiary care hospital in Gujarat, India


Nutanbala N Goswami1, Hiren R Trivedi2, Alpesh Puri P Goswami3, Tejas K Patel1, CB Tripathi1 
1 Department of Pharmacology, Govt. Medical College, Bhavnagar, India
2 Department of Pharmacology, M. P.Shah Medical College, Jamnagar, Gujarat, India
3 Department of Pathology, Govt. Medical College, Bhavnagar, India

Correspondence Address:
Nutanbala N Goswami
Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat - 364001
India

Objective: To find out the most common bacterial pathogens responsible for post-operative wound infection and their antibiotic sensitivity profile. Materials and Methods: This prospective, observational study was carried out in patients of postoperative wound infection. Samples from wound discharge were collected using a sterile swab and studied for identification of isolates by Gram stains and culture growth followed by in vitro antibiotic susceptibility testing performed by disc diffusion method on Mueller Hinton agar. Results: Out of 183 organisms, 126 (68.85%) isolated organisms were gram negative. Staphylococcus aureus, 48 (26.23%), was the predominant organism. S. aureus was sensitive to rifampicin (89.58%), levofloxacin (60.42%), and vancomycin (54.17%). Pseudomonas aeruginosa was sensitive to ciprofloxacin (83.78%), gatifloxacin (51.35%), and meropenem (51.35%). Escherichia coli was sensitive to levofloxacin (72.41%) and ciprofloxacin (62.07%). Klebsiella pneumoniae was sensitive to ciprofloxacin (63.16%), levofloxacin (63.16%), gatifloxacin (63.16%), and linezolid (56.52%). Proteus mirabilis was sensitive to ciprofloxacin (75%) and linezolid (62.50). Proteus vulgaris was sensitive to ampicillin+sulbactam (57.14%) followed by levofloxacin (50%). Conclusions: There is an alarming increase of infections caused by antibiotic-resistant bacteria, particularly in the emergence of VRSA/VISA, meropenem, and third generation cephalosporin resistant Pseudomonas aeruginosa. Linezolid showing sensitivity against Gram negative bacteria.


How to cite this article:
Goswami NN, Trivedi HR, Goswami AP, Patel TK, Tripathi C B. Antibiotic sensitivity profile of bacterial pathogens in postoperative wound infections at a tertiary care hospital in Gujarat, India.J Pharmacol Pharmacother 2011;2:158-164


How to cite this URL:
Goswami NN, Trivedi HR, Goswami AP, Patel TK, Tripathi C B. Antibiotic sensitivity profile of bacterial pathogens in postoperative wound infections at a tertiary care hospital in Gujarat, India. J Pharmacol Pharmacother [serial online] 2011 [cited 2021 Feb 25 ];2:158-164
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2011;volume=2;issue=3;spage=158;epage=164;aulast=Goswami;type=0