Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2012  |  Volume : 3  |  Issue : 1  |  Page : 39--42

Acute effects of granulocyte colony-stimulating factor on early ventricular arrhythmias after coronary occlusion in rats


Marcelo Perim Baldo, Sérgio Lamęgo Rodrigues, José Geraldo Mill 
 Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, Brazil

Correspondence Address:
Marcelo Perim Baldo
Department of Physiological Sciences, Federal University of Espirito Santo, Av. Marechal Campos, 1468 - 29042-751, Vitoria, ES
Brazil

Objectives: To evaluate the acute effects of colony-stimulating factor (G-CSF) on ventricular arrhythmias after coronary occlusion in rats. Materials and Methods: Male Wistar rats (10 weeks) received G-CSF (100 μg.kg -1 ) or vehicle. Thirty minutes later, animals were infarcted by coronary occlusion under artificial respiration. Electrocardiogram was monitored for 30 min to evaluate ventricular arrhythmias. Results: G-CSF treatment reduced the number of premature ventricular beats and the number and duration of ventricular tachycardia. The incidence of ventricular fibrillation was significantly reduced by G-CSF (MI-Cont: 11.2 ± 2.4 vs. MI-GCSF: 5.4 ± 1 events; P < 0.05). However, total duration of ventricular fibrillation was not altered (MI-Cont: 84 ± 16 vs. MI-GCSF: 76 ± 13 sec). Conclusions: Acute administration of G-CSF before coronary ligature in rats reduces the incidence of ventricular premature beats and ventricular tachycardia, suggesting a possible direct electrophysiological effect of this cytokine independently of its genomic effects. However, the data suggest that G-CSF treatment may affect the spontaneous recovery from ventricular fibrillation. Acute G-CSF administration acts directly on cardiac electrophysiology, different from chronic treatment.


How to cite this article:
Baldo MP, Rodrigues SL, Mill JG. Acute effects of granulocyte colony-stimulating factor on early ventricular arrhythmias after coronary occlusion in rats.J Pharmacol Pharmacother 2012;3:39-42


How to cite this URL:
Baldo MP, Rodrigues SL, Mill JG. Acute effects of granulocyte colony-stimulating factor on early ventricular arrhythmias after coronary occlusion in rats. J Pharmacol Pharmacother [serial online] 2012 [cited 2021 Apr 22 ];3:39-42
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2012;volume=3;issue=1;spage=39;epage=42;aulast=Baldo;type=0