Journal of Pharmacology and Pharmacotherapeutics

NEWS AND VIEWS
Year
: 2013  |  Volume : 4  |  Issue : 3  |  Page : 223--224

Baldness, a new marker for coronary heart disease risk


G Sivagnanam 
 Department of Pharmacology, Indira Gandhi Medical College and Research Institute, Kadhirkamam, Puducherry, India

Correspondence Address:
G Sivagnanam
Department of Pharmacology, Indira Gandhi Medical College and Research Institute, Kadhirkamam, Puducherry
India




How to cite this article:
Sivagnanam G. Baldness, a new marker for coronary heart disease risk.J Pharmacol Pharmacother 2013;4:223-224


How to cite this URL:
Sivagnanam G. Baldness, a new marker for coronary heart disease risk. J Pharmacol Pharmacother [serial online] 2013 [cited 2021 Jan 21 ];4:223-224
Available from: http://www.jpharmacol.com/text.asp?2013/4/3/223/114620


Full Text

 New(S)



Male pattern baldness is linked to an increased risk of coronary heart disease (CHD), but only if it's on the top/crown of the head, rather than at the front. [1]

 (Re)Views



A positive association between male pattern baldness and insulin resistance, [2] metabolic syndrome, [3] and hypertension [4] have been shown earlier.

A meta-analysis of observational studies comprising a total of 36,690 participants showed that vertex baldness is associated with an increased risk of CHD with the relationship depending on the severity of baldness while frontal baldness is not. Thus, it has been suggested that, vertex baldness might be a marker of CHD and is more closely associated with systemic atherosclerosis. [5]

The effectiveness of minoxidil (vasodilator) only in vertex baldness and not in frontal baldness, [6] also supports the finding that vertex baldness is more closely related to atherosclerosis than frontal one. Though the reason for the association between baldness and CHD is unclear, the possible mechanisms suggested include hyperinsulinemia, chronic inflammation, and increased peripheral sensitivity to androgens.

Like blood grouping, why not the male type baldness grouped into the following categories?

O (vertex)M (frontal)OM (vertex and frontal)Inverted U (O merged with M) andT (Total)Men of all groups except group M be wary of CHD.

References

1Available from: http://www.sciencedaily.com/releases/2013/04/ 130403200156.htm. [Last accessed on 2013 Apr 23].
2Mumcuoglu C, Ekmekci TR, Ucak S. The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia. Eur J Dermatol 2011;21:79-82.
3Su LH, Chen TH. Association of androgenetic alopecia with metabolic syndrome in men: A community-based survey. Br J Dermatol 2010;163:371-7.
4Ahouansou S, Le Toumelin P, Crickx B, Descamps V. Association of androgenetic alopecia and hypertension. Eur J Dermatol 2007;17:220-2.
5Yamada T, Hara K, Umematsu H, Kadowaki T. Male pattern baldness and its association with coronary heart disease: A meta-analysis. BMJ Open 2013;3:e002537 doi:10.1136/bmjopen-2012-002537
6Scow DT, Nolte RS, Shaughnessy AF. Medical treatments for balding in men. Am Fam Physician 1999;59:2189-94, 2196.