Journal of Pharmacology and Pharmacotherapeutics

MOLECULES OF THE MILLENNIUM
Year
: 2015  |  Volume : 6  |  Issue : 2  |  Page : 118--121

Suvorexant: The first orexin receptor antagonist to treat insomnia


Ashok K Dubey, Shailendra S Handu, Pramod K Mediratta 
 Department of Pharmacology, School of Medical Sciences and Research, Greater Noida, Uttar Pradesh, India

Correspondence Address:
Ashok K Dubey
Department of Pharmacology, School of Medical Sciences and Research, Greater Noida - 201 306, Uttar Pradesh
India

Primary insomnia is mainly treated with drugs acting on benzodiazepine receptors and a few other classes of drugs used for different co-morbidities. A novel approach to treat insomnia has been introduced recently, with the approval of suvorexant, the first in a new class of orexin receptor antagonists. Orexin receptors in the brain have been found to play an important role in the regulation of various aspects of arousal and motivation. The drugs commonly used for insomnia therapy to date, have often been associated with adverse effects, such as, day-time somnolence, amnesia, confusion, and gait disturbance, apart from the risk of dependence on chronic use. Suvorexant has not shown these adverse effects because of its unique mechanism of action. It also appears to be suitable as a chronic therapy for insomnia, because of minimal physical dependence. The availability of this new drug as an effective and safe alternative is an important and welcome development in insomnia management.


How to cite this article:
Dubey AK, Handu SS, Mediratta PK. Suvorexant: The first orexin receptor antagonist to treat insomnia.J Pharmacol Pharmacother 2015;6:118-121


How to cite this URL:
Dubey AK, Handu SS, Mediratta PK. Suvorexant: The first orexin receptor antagonist to treat insomnia. J Pharmacol Pharmacother [serial online] 2015 [cited 2022 Jan 19 ];6:118-121
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2015;volume=6;issue=2;spage=118;epage=121;aulast=Dubey;type=0