Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2020  |  Volume : 11  |  Issue : 1  |  Page : 13--18

Effect of nebivolol on microalbuminuria in hypertensive patients with or without type 2 diabetes mellitus


Padma Latha Merugu1, Thrilok Chander Bingi2 
1 Department of Pharmacology, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana, India
2 Department of General Medicine, Gandhi Medical College/Hospital, Secunderabad, Telangana, India

Correspondence Address:
Thrilok Chander Bingi
Flat No: 605, Namita Everest, Bahadurguda, L.B. Nagar, Ranga Reddy, Hyderabad - 500 074, Telangana
India

Objective: To evaluate the effect of nebivolol on microalbuminuria (MA) in hypertensive patients with or without type 2 diabetes mellitus. Materials and Methods: This was an open-label, prospective study. Drug naive patients with stage I hypertension with or without type 2 DM with MA (urine albumin: creatinine ratio [UACR] between 30–300 mg/g) were enrolled in the study and were started on nebivolol 5 mg orally once daily. Efficacy parameters UACR, blood pressure (BP) were measured at baseline and 24 weeks. Paired t-test was used to analyze efficacy endpoints. P < 0.05 was considered to be statistically significant. Results: A total of 30 participants completed the study. Participants who received nebivolol showed a significant decrease in mean UACR, systolic BP, and diastolic BP at 24 weeks compared to baseline (P < 0.001). No participant discontinued the study because of adverse events. Conclusion: Nebivolol has a favorable effect on MA in addition to its antihypertensive effect in hypertensive patients. Further studies with large samples are required to characterize this effect of nebivolol on clinical outcomes.


How to cite this article:
Merugu PL, Bingi TC. Effect of nebivolol on microalbuminuria in hypertensive patients with or without type 2 diabetes mellitus.J Pharmacol Pharmacother 2020;11:13-18


How to cite this URL:
Merugu PL, Bingi TC. Effect of nebivolol on microalbuminuria in hypertensive patients with or without type 2 diabetes mellitus. J Pharmacol Pharmacother [serial online] 2020 [cited 2020 Oct 24 ];11:13-18
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2020;volume=11;issue=1;spage=13;epage=18;aulast=Merugu;type=0