Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2020  |  Volume : 11  |  Issue : 1  |  Page : 8--12

The effects of a single preanesthetic dose of dexmedetomidine on propofol induction, hemodynamics, and cardiovascular parameters


Padmini Vishwanath, Rammoorthi Rao, Sunil Baikadi Vasudevarao 
 Department of Anaesthesia, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India

Correspondence Address:
Sunil Baikadi Vasudevarao
Kasturba Medical College, Mangalore, Karnataka
India

Objective: To find out the dose of propofol consumption for induction and also the variation in hemodynamics following single-dose dexmedetomidine premedication. Methods: A total of 60 American Society of Anesthesiologists Class 1 and 2 patients aged between 18 and 80 years, posted for elective surgeries were randomized into two groups: Group C – premedication with 2 mcg/kg fentanyl and Group D – premedication with 1 mcg/kg dexmedetomidine + 2 mcg/kg fentanyl. Both groups were preloaded with 10 ml/kg crystalloid solution. The parameters measured were propofol requirements, heart rate (HR), mean arterial pressure (MAP), cardiac index (CI), cardiac output (CO), and stroke volume variation (SVV). Results: Propofol requirements were 26.6% lesser in Group D (P < 0.001). In Group C, HR was significantly low at baseline (P = 0.008), induction (P = 0.006), and at intubation (P = 0.001) in Group D. Cardiovascular parameters such as MAP (P = 0.007), CI (P = 0.038), and CO (P = 0.021) were significantly lower in Group D compared to Group C only at baseline. There were no differences at any other point during the study. SVV was noted to be significantly lower (P = 0.018) in Group D only at intubation. Conclusion: Dexmedetomidine decreases the requirements of propofol for induction and also attenuates the hemodynamic response to intubation. Cardiovascular parameters such as MAP, CI, and CO were significantly lower in Group D only at baseline. Hemodynamic stability is mainly attributed to adequate preloading and less propofol requirement in the dexmedetomidine group.


How to cite this article:
Vishwanath P, Rao R, Vasudevarao SB. The effects of a single preanesthetic dose of dexmedetomidine on propofol induction, hemodynamics, and cardiovascular parameters.J Pharmacol Pharmacother 2020;11:8-12


How to cite this URL:
Vishwanath P, Rao R, Vasudevarao SB. The effects of a single preanesthetic dose of dexmedetomidine on propofol induction, hemodynamics, and cardiovascular parameters. J Pharmacol Pharmacother [serial online] 2020 [cited 2020 Oct 29 ];11:8-12
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2020;volume=11;issue=1;spage=8;epage=12;aulast=Vishwanath;type=0