Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2020  |  Volume : 11  |  Issue : 2  |  Page : 44--52

Curcumin improves the behavior and memory in mice by modulating the core circadian genes and their associated micro-RNAs


Dhondup Namgyal1, Kumari Chandan3, Sher Ali2, Rachna Mehta2, Maryam Sarwat4 
1 Amity Institute of Neuropsychology and Neuroscience, Amity University; Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India
2 School of Basic Sciences and Research, Department of Life Sciences, Sharda University, Greater Noida, Uttar Pradesh, India

Correspondence Address:
Maryam Sarwat
Amity Institute of Pharmacy, Amity University, Noida - 201303, Uttar Pradesh
India

Objective: To investigate the neuroprotective effects of curcumin in albino mice focusing on memory and behavior. Materials and Methods: Four groups of 7 mice each, different concentrations of curcumin were administered for 3 weeks in 3 groups and the remaining group was kept as control. The effect of curcumin on behavior and memory was studied using various tests. The expression of core circadian rhythm genes and micro RNAs were also studied. Results: Our results revealed that curcumin improves the mice's behavior by regulating oxidative stress, hippocampal neurogenesis, and modulation of core circadian genes and their associated micro-RNA. Conclusion: This study shows that curcumin has a potential neuroprotective effect.


How to cite this article:
Namgyal D, Chandan K, Ali S, Mehta R, Sarwat M. Curcumin improves the behavior and memory in mice by modulating the core circadian genes and their associated micro-RNAs.J Pharmacol Pharmacother 2020;11:44-52


How to cite this URL:
Namgyal D, Chandan K, Ali S, Mehta R, Sarwat M. Curcumin improves the behavior and memory in mice by modulating the core circadian genes and their associated micro-RNAs. J Pharmacol Pharmacother [serial online] 2020 [cited 2020 Nov 26 ];11:44-52
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2020;volume=11;issue=2;spage=44;epage=52;aulast=Namgyal;type=0