Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2021  |  Volume : 12  |  Issue : 1  |  Page : 14--19

Effect of HMG-Co-A reductase inhibitors on cardiac autonomic neuropathy in diabetic patients


Aarya Jitendra Kshirsagar1, Yogita Karandikar2, Leena Phadake3 
1 Intern, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India
2 Departments of Pharmacology, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India
3 Department of Physiology, Central Research Lab, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India

Correspondence Address:
Yogita Karandikar
3, Nayananand Society, Anandnagar, Sinhgad Road, Pune - 411 051, Maharashtra
India

Objective: To observe the effect of statins on cardiac autonomic neuropathy in patients with diabetes and to study the correlation between cardiac autonomic neuropathy as assessed by cardiac autonomic reflex tests (CARTs) and by Composite Autonomic Symptom Scale (COMPASS)-31. Materials and Methods: A cross-sectional observational study was conducted on 62 patients having Type 2 diabetes mellitus for more than 5 years. Patients were randomized into two groups, one group received standard antidiabetic therapy and other group received standard antidiabetic along with statin medication at least for more than 1 year. Each patient underwent CART and heart rate variability to assess autonomic dysfunction. In addition, COMPASS 31 questionnaire was used to evaluate symptoms subjectively. Statin Experience Assessment Questionnaire was used to note adverse effects of statins. Chi-square test, Spearman correlation test, and Mann–Whitney U-test were used for statistical analysis. Results: A significant difference in severity of cardiac autonomic dysfunction was observed between two groups as measured by CART (P = 0.016) and COMPASS-31 questionnaire (P = 0.008). Moreover, COMPASS score of >16 was observed in patients with advanced cardiac autonomic neuropathy. A significant correlation was found between COMPASS 31 score and CART results (r = 0.29, P = 0.02). Conclusion: Our study highlights the potential utility of statins in curbing progression of cardiac autonomic neuropathy and can be safely administered in patients with Type 2 diabetes mellitus. COMPASS 31 questionnaire can be used as an effective screening tool for CART referral, facilitating the early detection of cardiac autonomic neuropathy.


How to cite this article:
Kshirsagar AJ, Karandikar Y, Phadake L. Effect of HMG-Co-A reductase inhibitors on cardiac autonomic neuropathy in diabetic patients.J Pharmacol Pharmacother 2021;12:14-19


How to cite this URL:
Kshirsagar AJ, Karandikar Y, Phadake L. Effect of HMG-Co-A reductase inhibitors on cardiac autonomic neuropathy in diabetic patients. J Pharmacol Pharmacother [serial online] 2021 [cited 2021 Sep 19 ];12:14-19
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2021;volume=12;issue=1;spage=14;epage=19;aulast=Kshirsagar;type=0