Journal of Pharmacology and Pharmacotherapeutics

RESEARCH PAPER
Year
: 2021  |  Volume : 12  |  Issue : 2  |  Page : 47--53

Vitamin D3 attenuates type 3 diabetic-associated cognitive deficits in rats through regulating neurotrophins and enhancing cholinergic transmission pathway


Yahya Abdullah Al-Zahrani1, Mai A. Alim A. Sattar2, Sameer E Al-Harthi2, Ayed A Alkatheeri1, Yahya Mohammed Al-Zahrani3 
1 Department of Pharmacy, East Jeddah Hospital, Ministry of Health, Jeddah, Saudi Arabia
2 Department of Medical Pharmacology, College of Medicine, King Abdul-Aziz University, Jeddah, Saudi Arabia
3 Department of Pharmacy, Directorate of Public Health, Ministry of Health, Makkah, Saudi Arabia

Correspondence Address:
Yahya Mohammed Al-Zahrani
Department of Pharmacy, Directorate of Public Health, Ministry of Health, Makkah
Saudi Arabia

Objective: To examine the protective effect of Vitamin D3 against Type 3 diabetes-induced cognitive dysfunction in rats. Materials and Methods: Type 3 diabetes was induced by a high-fat diet plus streptozotocin in rats. Rats were divided into seven groups: negative control, positive control, Vitamin D3 groups (100, 500 and 1000 IU/kg/day), Vitamin D3 plus rivastigmine, and rivastigmine monotherapy. A radial arm maze test was used to assess cognitive function. Levels of acetylcholinesterase (AChE), dopamine (DA), nerve growth factor, neurotrophin-3 (NT-3), and glial cell line-derived neurotrophic factor (GDNF) in the hippocampus were estimated by the enzyme-linked immunosorbent assay kits. Results: Chronic treatment with Vitamin D3 significantly (P < 0.05) and dose dependently alleviated cognitive deficits, with enhancing cholinergic transmission pathway activity through attenuated hippocampal AChE and increased DA level (P < 0.001). Moreover, Vitamin D3 significantly increased (P < 0.001) neurotrophin levels as an underlying mechanism for the resulted improvement. Conclusion: Vitamin D3 plus rivastigmine (combined group) is better than Vitamin D (100 and 500 mg/kg/day) for improvement of AChE, DA, NT-3, and GDNF levels. Vitamin D (500 and 1000 IU/kg/day) was effective as a combined group in terms of the behavioral test.


How to cite this article:
Al-Zahrani YA, Sattar MA, Al-Harthi SE, Alkatheeri AA, Al-Zahrani YM. Vitamin D3 attenuates type 3 diabetic-associated cognitive deficits in rats through regulating neurotrophins and enhancing cholinergic transmission pathway.J Pharmacol Pharmacother 2021;12:47-53


How to cite this URL:
Al-Zahrani YA, Sattar MA, Al-Harthi SE, Alkatheeri AA, Al-Zahrani YM. Vitamin D3 attenuates type 3 diabetic-associated cognitive deficits in rats through regulating neurotrophins and enhancing cholinergic transmission pathway. J Pharmacol Pharmacother [serial online] 2021 [cited 2021 Nov 28 ];12:47-53
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2021;volume=12;issue=2;spage=47;epage=53;aulast=Al-Zahrani;type=0