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EDITORIAL |
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Push, promote or educate…musings of a pharmacologist on drug promotion
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p. 225 |
Chanolean Shashindran DOI:10.4103/0976-500X.142427 PMID:25422560 |
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REVIEW ARTICLE |
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Management of diabetes in the elderly with canagliflozin: A newer hypoglycemic drug on the horizon
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p. 227 |
Vishal Sehgal, Sukhminder Jit Singh Bajwa, Rinku Sehgal, John A Consalvo DOI:10.4103/0976-500X.142428 PMID:25422561Canagliflozin is the first available oral inhibitor of sodium/glucose cotransporter 2 (SGLT2) in the market. At the outset it sounds excellent for the use in the elderly diabetic population, because of its minimal tendency to cause hypoglycemia. However, the clinician needs to exercise caution as it needs to be dosed renally. The clinician needs to be circumspect about potential drug interactions, especially when there is an underlying chronic kidney disease (CKD) and congestive heart failure (CHF). Also its use is best avoided in people who are predisposed to genital mycotic and urinary tract infections (UTI). |
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RESEARCH PAPERS |
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Acetylated and propionated derivatives of swertiamarin have anti-adipogenic effects
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p. 232 |
Hitesh B Vaidya, Ramesh K Goyal, Sukhinder K Cheema DOI:10.4103/0976-500X.142429 PMID:25422562Objective: To investigate whether the acetylated and propionated derivatives (LMP-09-1 and -2) of swertiamarin have anti-adipogenic effects. Materials and Methods: 3T3-L1 pre-adipocytes were grown in Dulbecco's Modified Eagle's Medium (DMEM) containing 10% calf serum; fully confluent cells were differentiated with insulin, dexamethasone, and 3-isobutylmethylxanthine in the presence and absence of LMP-09-1 and -2 (100 μg/mL) for 10 days. Control cells received same amount of dimethylsulfoxide (DMSO). On day ten, cells were analyzed for triglycerides accumulation and the expression of genes involved in adipogenesis, lipogenesis, and lipolysis. In another set of experiment, effects of LMP-09-1 and 2 were studied for isoproterenol induced lipolysis using fully mature adipocytes. Results: LMP-09-1 and -2 caused a significant (P < 0.001) reduction in intracellular triglycerides accumulation. Both LMP-09-1 and -2 significantly (P < 0.001) decreased the mRNA expression of peroxisome proliferator activated receptor-γ and acetyl-CoA carboxylase-1, and increased isoproterenol induced lipolysis in adipocytes. LMP-09-1 induced lipolysis even in the absence of isoproterenol, and also showed a significant up-regulation of carnitine palmitoyl transferase-1α and hormone sensitive lipase (HSL) gene expression. Conclusions: These findings show that swertiamarin derivatives, LMP-09-1 and -2 have a potent anti-adipogenic effect. |
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Oral carvedilol in escalating doses in the acute treatment of atrial fibrillation
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p. 239 |
Ravi Venkatachelam Chitrapu, Pentakota Ramana Rao, Gangireddy Venkateswara Reddy DOI:10.4103/0976-500X.142430 PMID:25422563Objective: To study the efficacy of oral carvedilol in acute treatment of atrial fibrillation (AF) with fast ventricular rate. Materials and Methods: In an open-label, single-arm trial, oral carvedilol was administered to 35 patients of AF in escalating doses from 3.125 mg o.d. to 12.5 mg b.i.d. Results: A successful result was seen in 25 patients (71.4%) with 4 converting to sinus rhythm, rate control to less than 90 bpm in 16 and a 20% rate reduction in 5 patients. Two patients developed hypotension needing withdrawal of the drug. Conclusion: Escalating doses of oral carvedilol can be effectively and safely used in the acute treatment of AF with fast ventricular rate. |
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CORRESPONDENCE |
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The impact of irrational practices: A wake up call
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p. 245 |
Meena Garg, Pinki Vishwakarma, Monica Sharma, Rajiv Nehra, KK Saxena DOI:10.4103/0976-500X.142434 PMID:25422564 |
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RESEARCH LETTERS |
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Pharmacovigilance and adverse drug reaction reporting perspectives among interns and postgraduates of a teaching hospital
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p. 248 |
Raghava Sharma, Adithi Kellarai DOI:10.4103/0976-500X.142436 PMID:25422565 |
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Evaluation of potassium clavulanate on ethanol consumption and decision making in the model of ethanol dependence in mice
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p. 250 |
Kshitij S Jadhav, Padmaja A Marathe DOI:10.4103/0976-500X.142439 PMID:25422566 |
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Antimicrobial utilization in multidisciplinary intensive care units of a public tertiary care hospital
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p. 252 |
Gudapati Bhanu Naga Sireesha, Pramil Tiwari, Satinder Gombar, Sanjay D'Cruz, Atul Sachdev DOI:10.4103/0976-500X.142441 PMID:25422567 |
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Pediatric dosing errors due to variable drug formulations
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p. 254 |
Sumit Mehndiratta DOI:10.4103/0976-500X.142444 PMID:25422568 |
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CASE REPORTS |
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Oyster shell calcium induced parotid swelling
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p. 256 |
Muthiah Palaniappan, Sandhiya Selvarajan, Sureshkumar Srinivasamurthy, Adithan Chandrasekaran DOI:10.4103/0976-500X.142446 PMID:25422569A 59 year old female consumer was started on therapy with oyster shell calcium in combination with vitamin D3 and she presented with swelling below the ear, after two doses. She stopped the drug by herself and the swelling disappeared in one day. She started the drug one day after recovery and again she developed the swelling. She was advised to stop the drug with a suggestion to take lemon to enhance parotid secretion and the swelling subsided. Calcium plays major role in salivary secretion and studies have shown reduced parotid secretion in rats, deficient of vitamin D. But in humans involvement of calcium and vitamin D3 in parotid secretion is unknown. However, the patient had no history of reaction though she had previously taken vitamin D3 with calcium carbonate which was not from oyster shell. Hence, we ruled out vitamin D3 in this reaction and suspecting oyster shell calcium as a culprit. This adverse drug reaction (ADR) was assessed using World Health Organization (WHO) causality assessment, Naranjo's and Hartwig severity scales. As per WHO causality assessment scale, the ADR was classified as "certain". This reaction was analyzed as per Naranjo's algorithm and was classified as probable. According to Hartwig's severity scale the reaction was rated as mild. Our case is an example of a mild but rare adverse effect of oyster shell calcium carbonate which is widely used.
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Risperidone-induced mania: An emergent complication of treatment
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p. 258 |
Anjana Rao Kavoor, Sayantanava Mitra, Supriya Kumar Mondal, Basudeb Das DOI:10.4103/0976-500X.142448 PMID:25422570The occurrence of manic/hypomanic switch in patients being treated with risperidone has been reported by various authors, and they have described a variety of strategies for their management. In this report, we describe two cases of induction of elevated mood symptoms in patients treated with risperidone. We propose that the emergence of these symptoms may be a complication of treatment with this drug in susceptible individuals, of which the clinicians should be aware, mainly in those diagnosed with schizophrenia and bipolar disorder. We then discuss a few findings that might be useful in the management of such cases. We thereby also propose a mechanism for such an induction.
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Catatonia in mixed alcohol and benzodiazepine withdrawal
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p. 261 |
Aniruddha Basu, Amit Jagtiani, Rajiv Gupta DOI:10.4103/0976-500X.142449 PMID:25422571Catatonia is mostly caused by different neuropsychiatric conditions. We report a case of a 30 year old man suffering from both alcohol and benzodiazepine dependence who exhibited catatonic features soon after stopping the intake of substances. This case will help clinicians to recognize catatonic features within the varied symptomatology of substance withdrawal and thereby helping in its early diagnosis and management.
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Ganciclovir-tenofovir interaction leading to tenofovir-induced nephrotoxicity
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p. 265 |
Radhika Soanker, Shobha Jagdish Chandra Udutha, Malladi VS Subbalaxmi, YSN Raju DOI:10.4103/0976-500X.142452 PMID:25422572Viral enteritis is an important gastrointestinal disorder in human immunodeficiency virus (HIV)-infected patients. Cytomegalovirus (CMV) is the most common opportunistic agent in these patients. As ganciclovir and tenofovir are the most commonly used drugs for the treatment of CMV and HIV infection, respectively, this case report showcases the potentiality of drug interaction as well as the safety measures to be taken when using these two drugs together in unavoidable situations.
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Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure
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p. 268 |
Sachin R Agrawal, Atul Rajput, AP Jain DOI:10.4103/0976-500X.142453 PMID:25422573Leukocytoclastic vasculitis (LCV), also known as hypersensitivity vasculitis is a small vessel inflammatory disease which mainly involves the postcapillary venules. A 17-year-old girl developed palpable purpura over lower limbs and acute allergic interstitial nephritis 5 days after exposure to ceftriaxone. Skin biopsy from the lesion over lower limbs confirmed the diagnosis of LCV. Discontinuation of drug and treatment with steroid resulted in resolution of skin lesions and normalization of kidney functions. Beta-lactams are commonly used antibiotics in various types of infection in day-to-day practice. LCV, a rare complication of ceftriaxone should be kept in mind while using this drug. |
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Cutaneous adverse drug reaction type erythema multiforme major induced by eslicarbazepine
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p. 271 |
Andreu Massot, Ana Gimenez-Arnau DOI:10.4103/0976-500X.142456 PMID:25422574Severe skin reactions occur less frequently with eslicarbazepine (ESL) than with the other aromatic anticonvulsants. We report the first case of cutaneous adverse drug reaction (CADR) to ESL and co-sensitization between ESL and betalactams. A 41-year-old white woman developed focal epilepsy due to a meningioma that was removed. As post-operatory complication, she suffered meningitis as well as a maculo-papular erythema caused by the treatment with meropenem. Subsequently, ESL was started and gradually increased until 800 mg/day. Twenty-five days later, the patient developed an Erythema Multiforme Major (EMM). Strong positive immediate reaction was induced by prick test with carbamazepine (CBZ) and ESL at 0.01 and 0.1% within 15 and 30 minutes; however the delayed reading at 48 hours was negative. The patient was not carrier of the HLA alleles A3101 and B1502 associated with CBZ induced EMM. The hypersensitivity pathogenic mechanism of EMM is unclear and a delayed hypersensitivity process is speculated. However, the patch and intradermal tests in our patient did not show a delayed reaction but an immediate cutaneous one. A first allergic episode may elicit a massive nonspecific activation of the immune system, providing an enhanced expression of co-stimulatory molecules that decreases the level of tolerance to other drugs. When prescribing ESL, we suggest ruling out previous CADR, especially to CBZ and oxcarbazepine but also other chemically unrelated drugs such as beta-lactams. |
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NEWS AND VIEWS |
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Acetaminophen associated with risk of hearing loss: A safety alert
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p. 275 |
Sangeeta Bhanwra, Kaza Ahluwalia DOI:10.4103/0976-500X.142458 |
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WEBWISE |
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Mini Manuscript
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p. 276 |
Jatinder Singh DOI:10.4103/0976-500X.142462 PMID:25422575 |
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MOLECULES OF THE MILLENNIUM |
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Sofosbuvir: A novel treatment option for chronic hepatitis C infection
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p. 278 |
Harmeet Kaur Bhatia, Harmanjit Singh, Nipunjot Grewal, Navreet Kaur Natt DOI:10.4103/0976-500X.142464 PMID:25422576Hepatitis C currently infects more than 170 million people around the world, leading to significant morbidity and mortality. The current standard of care for HCV infection, including one of the two protease inhibitors, telaprevir or boceprevir, for 12-32 weeks, along with pegylated interferon alfa-2a (PEG-IFN-α) and ribavirin for up to 48 weeks, is unsatisfactory in many cases, either because of lack of efficacy or because of treatment-related adverse effects. There is an urgent need of new drugs with improved efficacy as well as a safety profile. Sofosbuvir, a recently approved nucleotide analog, is a highly potent inhibitor of the NS5B polymerase in the Hepatitis C virus (HCV), and has shown high efficacy in combination with several other drugs, with and without PEG-INF, against HCV. It offers many advantages due to its high potency, low side effects, oral administration, and high barrier to resistance. The efficacy and safety were demonstrated in many large and well-designed phase 2 and phase 3 clinical trials like NEUTRINO, PROTON, ELECTRON, ATOMIC, COSMOS, FUSION, FISSION, NUCLEAR, POSITRON, and the like. It is generally well-tolerated. Adverse events that occurred include: Headache, insomnia, fatigue, nausea, dizziness, pruritis, upper respiratory tract infections, rash, back pain, grade 1 anemia, and grade 4 lymphopenia; however, the exact safety profile can only be judged when this drug is actually used on a large scale.
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