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  Indian J Med Microbiol
 

Figure 1: Schematic diagram explaining the mechanism of action of Hedgehog (Hh) pathway. PTCH1 - Patched 1, transmembrane receptor; SMO - smoothened, transmembrane protein; Hh - Hedgehog. (a) shows that during normal conditions, PTCH1 keeps SMO under repression. (b) shows that Hh ligand binds to PTCH1 receptor and inhibits its inhibitory effect on SMO, thus promoting the signal transduction via Hh pathway

Figure 1: Schematic diagram explaining the mechanism of action of Hedgehog (Hh) pathway. PTCH1 - Patched 1, transmembrane receptor; SMO - smoothened, transmembrane protein; Hh - Hedgehog. (a) shows that during normal conditions, PTCH1 keeps SMO under repression. (b) shows that Hh ligand binds to PTCH1 receptor and inhibits its inhibitory effect on SMO, thus promoting the signal transduction via Hh pathway