Analysis of thyroid function tests in patients of multidrug resistance tuberculosis undergoing treatment

The study was conducted in compliance with good clinical practice guidelines, declaration of Helsinki and standard operating procedures of Institutional Ethics Committee (IEC). The study protocol and informed consent forms were approved by IEC. A written informed consent was obtained from all patients included in the study. Fifty-four patients (38 females and 16 males) were included in the study and the study participants received isoniazid, pyrazinamide, and second-line antitubercular drugs, such as Eto, PAS, cycloserine, kanamycin, ofloxacin, and clarithromycin. The effect of first- and second-line antituberculosis agents on thyroid function was monitored. All the patients included in the study were confi rmed cases of MDR-TB diagnosed by mycobacterial culture sensitivity. The study was conducted before the institution of DOTS PLUS in the state of Rajasthan and hence all the samples for culture sensitivity were sent to the New Delhi Tuberculosis Center New Delhi, New Delhi. Diagnosis was made using a conventional L. J. medium for culture method and the method recommended was proportion method. A standard technique (proportion method on a conventional L. J. medium) was used for performing drug sensitivity in every case. The species identifi cation was done in every case based on colony characteristics and time of appearance of growth in culture media followed by biochemical tests such as the niacin test and para-nitro benzoic acid (PNB) inhibition test.