Antiulcer screening of Carthamus tinctorius on volume and acidity of stimulated gastric secretion in rats

The ulcers that affect the gastrointestinal system are normally provoked by an imbalance between aggressive and protective factors in the stomach, which is affected by factors such as acid-pepsin secretion, mucosal barrier, mucus secretion, blood flow, cell regeneration, prostaglandins, and epidermal growth factors.[1] Stress, smoking, nutritional deficiencies, ingestion of nonsteroidal anti-inflammatory drugs, hereditary predisposition, and infection by Helicobacter pylori are all factors that can increase the incidence of gastric ulcer. [2] Moreover, calcium plays an important role in increased production of gastric acid. Induction of hypercalcemia through intravenous administration of calcium is usually associated with increased gastric volume and acidity. The acid stimulating ability of calcium is well known, and there is extreme sensitivity to calcium in patients with Z.E. syndrome.