L-Asparaginase induced thrombosis in acute lymphoblastic leukemia

As the authors have pointed out, the risk of symptomatic thrombosis in childhood acute leukemia is approximately 5%.[2] However, asymptomatic and symptomatic thrombosis may be observed in as many 73% of the ALL patients with central lines and treated with chemotherapy.[2] Akin to the reported patient, most patients are diagnosed with thrombosis during induction therapy.[3] It would be useful to know if the index patient had any central lines, co-morbidities, or inter-current illnesses. Although central lines are not directly related to CVT, they often cause other central venous thrombosis.