Old wine, old bottle, new customer

• 2012;345:e4260. 2012;345:e4260.^1*

1. ¹Gullestad L, Aukrust P, Ueland T, Espevik T, Yee G, Vagelos R, et al. Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure. J Am Coll Cardiol 1999;34:2061-7. 4. Morice AH, Lowry R, Brown MJ, Higenbottam T. Angiotensinconverting enzyme and the cough reflex. Lancet 1987;2:1116-8. 5. Sekizawa K, Ujiie Y, Itabashi S, Sasaki H, Takishima T. Lack of cough reflex in aspiration pneumonia. Lancet 1990;335:1228-9. Old wine, old bottle, new customer New(S) The cheap injection that might be able to save a soldier’s life. It has been roughly estimated that it would take about 4 h for injured soldiers to receive a blood transfusion at a hospital. Researchers at Massachusetts General Hospital wondered whether histone deacetylase (HDAC) inhibitors could counter and prevent organ failure in instances of rapid blood loss. Pigs were divided into three groups and were drained of 60% of their blood. Group 1 received saline infusion, group 2 received valproic acid (HDAC inhibitor) injection, and group 3 blood transfusion. Survival at the end of 4 h was 25%, 86%, and 100%, respectively. A similar effect in humans by valproic acid.

Published in Journal of Pharmacology and Pharmacotherapeutics