Modulation of conditioned avoidance response and quetiapine‑induced metabolic syndrome by rosuvastatin and CDP‑choline in rats

The rats (Wistar rat) were divided into nine groups, each group containing eight rats. In this study, psychotic symptoms were induced in rats through Conditioned Avoidance Response (CAR) using Cook’s pole climbing apparatus. After the induction of CAR training of animal for 7 days, drug treatment was given for 21 days [Table 1]. On 22nd day under light anesthesia 1 ml of blood was collected through retro‑orbital sinus[6] for estimation of blood glucose and triglyceride level and then the animals were sacrificed to determine the liver glycogen concentration. This study was approved by the Institutional Animal Ethics Committee, Jamia Hamdard, New Delhi. Statistical analysis used mean ± SEM, analysis of variance (ANOVA), followed by Dunnett’s t‑test. Values were considered statistically significant, when P < 0.05.